Genetic Testing for Statin Induced Myopathy

STATIN-INDUCED MYOPATHY Statins are associated with a known risk of muscle-related symptoms, which are the most common adverse effects of statin drugs. Myopathy is a general term for muscle toxicity. Three categories of statin-induced myopathy have been defined by a joint committee of the American College of Cardiology, American Heart Association, and National Heart, Lung and Blood Institute:  Statin-induced myalgia, defined as any muscle symptoms that occur without an elevation of serum creatinine kinase (CK);  Statin-induced myositis, defined as muscle symptoms with an elevation of serum CK; and  Statin-induced rhabdomyolysis, defined as markedly severe muscle symptoms with an elevation of CK greater than 10 times normal with an elevation in serum creatinine.